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Image Search Results
Journal: Frontiers in Veterinary Science
Article Title: Investigation of the impact of clonal hematopoiesis on severity and pathophysiology of COVID-19 in rhesus macaques
doi: 10.3389/fvets.2023.1182197
Figure Lengend Snippet: Post-challenge inflammatory response and viral load in macaques with CH. (A) Post-challenge BALF cytokine/chemokines levels in CH macaques vs. controls. Box plots depicting the results of immunoassays for rhesus macaque MCP-1, IL-1β, MIP-1β, IL-6, and IL-8. (B) Assessment of viral replication in BALF and nasal swab specimens by SARS-CoV-2 envelope (E) and nucleocapsid (N) sgRNA quantification. Each colored symbol indicates individual macaques and the dashed horizontal lines show the limit of detection for the assay.
Article Snippet: Concentrations of major cytokines and chemokines in serum and BAL were measured using
Techniques:
Journal: PLoS Neglected Tropical Diseases
Article Title: Crimean-Congo hemorrhagic fever virus strains Hoti and Afghanistan cause viremia and mild clinical disease in cynomolgus monkeys
doi: 10.1371/journal.pntd.0008637
Figure Lengend Snippet: Whole blood was collected from each animal at the indicated time points post infection and assayed for circulating serum cytokine and chemokines using a panel of 23 analytes (see ). Analytes depicted were chosen based on an obvious shift from baseline in most or all animals, their relevance in human infection, or for comparison against those reported in Haddock et al. (16). Individual points (red or black circles) are the mean value of two technical replicates from the same sample, corresponding bars indicate the mean value for the group. Error bars indicate the upper SD. The number of individuals assayed at each time point (n) is indicated above error bar. (A) IL-6; (B) IL-1RA; (C) IL-10; (D) sCD-40L. Note that due to differences in the sampling schedule between studies, data is not available for Afghanistan animals at the day 2 timepoint.
Article Snippet: Circulating levels of 23 cytokines/chemokines in sera of CCHFV-infected macaques were measured using the
Techniques: Infection, Comparison, Sampling